Joe Sorg's lab in the Department of Biology at Texas A&M University investigates Clostridium difficile physiology and virulence with the end goal of developing novel antimicrobials to combat this pathogen.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Recent PublicationsShrestha, R., Cochran, AM., Sorg, JA. The requirement for co-germinants during C. difficile spore germination is influenced by mutations in yabG and cspA. PLoS Pathog. 2019 Apr 3;15(4):e1007681. doi: 10.1371/journal.ppat.1007681.
Shrestha, R., Sorg, JA. (2019) Terbium chloride influences Clostridium difficile spore germination. Anaerobe. Mar 26. pii: S1075-9964(19)30063-0. doi: 10.1016/j.anaerobe.2019.03.016. Bouillaut, L., Dubois, T., Francis, MB., Daou, N., Monot, M., Sorg, JA., Sonenshein, AL., Dupuy B. (2019) Role of the global regulator Rex in control of NAD+-regeneration in Clostridioides (Clostridium) difficile. Mol Microbiol. 2019 Mar 18. doi: 10.1111/mmi. 12345 Savidge, T., Sorg, JA. (2019) Role of Bile in Infectious Disease: the Gall of 7a-dehydroxylating bacteria. Cell Chem Biol. 2019 Jan 17;26(1): 1-3. doi: 10.1016/j.chembiol.2018.12.010 Bhattacharjee, D., Sorg, JA. (2018) Conservation of the "Outside - in" germination pathway in Paraclostridium bifermentans. Front. Microbiol. 9:2487. doi: 10.3389/fmicb.2018.02487 Zhu, D., Sorg, JA., Sun, X.(2018) Clostridioides difficile Biology: Sporulation, germination, and corresponding therapies for C. difficile infection. Front Cell Infect Microbiol. 2018 Feb 8;8.29. doi: 10.3389/fcimb.2018.00029 Shrestha, R., Sorg, JA. (2018) Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination. Anaerobe. 2018 Feb;49:41-47. doi: 10.1016/j.anaerobe.2017.12.001. McAllister, KN., Bouillaut, L., Kahn, JN., Self, WT., Sorg, JA. (2017) Using CRISPR-Cas9-mediated genome editing to generate C. difficile mutants defective in selenoproteins synthesis. Scientific Reports. 7 Article number: 14672. doi:10.1038/s41598-017-15236-5 |
Members of the Sorg Lab
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