Joe Sorg's lab in the Department of Biology at Texas A&M University investigates Clostridium difficile physiology and virulence with the end goal of developing novel antimicrobials to combat this pathogen.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Recent PublicationsBaloh, M., Nerber, HN., Sorg, JA. Imaging Clostridioides difficile spore germination and germination proteins. J Bacteriol. 2022 Jul 19;204(7):e0021022. doi: 10.1128/jb.00210-22.
Chandra, H., Sorg, JA., Hassett, DJ., Sun, X. Regulatory transcription factors of Clostridioides difficile pathogenesis with a focus on toxin regulation. Crit Rev Microbiol. 2022 Apr 7:1-16. doi: 10.1080/1040841X.2022.2054307 Baloh, M., Sorg, JA. Clostridioides difficile spore germination: initiation to DPA release. Curr Opin Microbiol. 2022 Feb;65:101-107. doi: 10.1016/j.mib.2021.11.001. Aguirre, AM., Sorg, JA. Gut associated metabolites and their roles in Clostridioides difficile pathogenesis. Gut Microbes. 2022 Jan-Dec;14(1):2094672. doi: 10.1080/19490976.2022.2094672. Aguirre, AM., Yalcinkaya, N., Wu, Q., Swennes, A., Tessier, ME., Roberts, P., Miyajima, F., Savidge, T., Sorg, JA. Bile acid-independent protection against Clostridioides difficile infection. PLoS Pathog. 2021 Oct 19;17(10):e1010015. doi: 10.1371/journal.ppat.1010015. Nerber, HN., Sorg, JA. The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation. PLoS Pathog 2021 Sep 8;17(9):e1009516. doi: 10.1371/journal.ppat.1009516 Baloh, M., Sorg, JA. Clostridioides difficile SpoVAD and SpoVAE interact and are required for DPA uptake into spores. J Bacteriol. 2021 Aug 23:JB0039421 . doi: 10.1128/JB.00394-21 McAllister, KN., Martinez AA., Sorg, JA. The selenophosphate synthetase, selD, is important for Clostridioides difficile physiology. J Bacteriol. 2021 Apr 5:JB.00008-21. doi: 10.1128/JB.00008-21. Engevik, MA., Danhof, HA., Shrestha, R., Chang-Graham, AL., Hyser, JM., Hyser, JM., Haag, AM., Mohammad, MA., Britton, RA., Versalovic, J., Sorg, JA., Spinler, JK. Reuterin distrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation. Gut Microbes. 2020. Nov 9;12(1):1788898. doi: 10.1080/19490976.2020.1795388 |
Members of the Sorg Lab
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