Joe Sorg's lab in the Department of Biology at Texas A&M University investigates Clostridium difficile physiology and virulence with the end goal of developing novel antimicrobials to combat this pathogen.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Recent PublicationsNerber, HN., Sorg, JA. The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation. PLoS Pathog 2021 Sep 8;17(9):e1009516. doi: 10.1371/journal.ppat.1009516
Baloh, M., Sorg, JA. Clostridioides difficile SpoVAD and SpoVAE interact and are required for DPA uptake into spores. J Bacteriol. 2021 Aug 23:JB0039421 . doi: 10.1128/JB.00394-21 McAllister, KN., Martinez AA., Sorg, JA. The selenophosphate synthetase, selD, is important for Clostridioides difficile physiology. J Bacteriol. 2021 Apr 5:JB.00008-21. doi: 10.1128/JB.00008-21. Engevik, MA., Danhof, HA., Shrestha, R., Chang-Graham, AL., Hyser, JM., Hyser, JM., Haag, AM., Mohammad, MA., Britton, RA., Versalovic, J., Sorg, JA., Spinler, JK. Reuterin distrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation. Gut Microbes. 2020. Nov 9;12(1):1788898. doi: 10.1080/19490976.2020.1795388 Bhattacharjee, D., Sorg, JA. Factors and conditions that impact electroporation of Clostridioides difficile strains. mSphere. 2020 Mar 4;5(2):e00941 - 19. doi: 10.1128/mSphere.00941-19. McAllister, KN., Sorg, JA. CRISPR Genome Editing Systems in the Genus Clostridium: A Timely Advancement. J Bacteriol. 2019 Jul 24;201(16). pii: e00219-19. doi: 10.1128/JB.00219-19. Shrestha, R., Cochran, AM., Sorg, JA. The requirement for co-germinants during C. difficile spore germination is influenced by mutations in yabG and cspA. PLoS Pathog. 2019 Apr 3;15(4):e1007681. doi: 10.1371/journal.ppat.1007681. |
Members of the Sorg Lab
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