Joe Sorg's lab in the Department of Biology at Texas A&M University investigates Clostridium difficile physiology and virulence with the end goal of developing novel antimicrobials to combat this pathogen.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Recent PublicationsBhattacharjee, D., Sorg, JA. (2018) Conservation of the "Outside - in" germination pathway in Paraclostridium bifermentans. Front. Microbiol. 9:2487. doi: 10.3389/fmicb.2018.02487
Zhu, D., Sorg, JA., Sun, X.(2018) Clostridioides difficile Biology: Sporulation, germination, and corresponding therapies for C. difficile infection. Front Cell Infect Microbiol. 2018 Feb 8;8.29. doi: 10.3389/fcimb.2018.00029 Shrestha, R., Sorg, JA. (2018) Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination. Anaerobe. 2018 Feb;49:41-47. doi: 10.1016/j.anaerobe.2017.12.001. McAllister, KN., Bouillaut, L., Kahn, JN., Self, WT., Sorg, JA. (2017) Using CRISPR-Cas9-mediated genome editing to generate C. difficile mutants defective in selenoproteins synthesis. Scientific Reports. 7 Article number: 14672. doi:10.1038/s41598-017-15236-5 Shrestha, R., Lockless, SW., Sorg, JA. (2017) A Clostridium difficile alanine racemase affects spore germination and accommodates serine as a substrate. J. Biol. Chem. Jun 23;292(25):10735-10742. doi: 10.1074/jbc.M117.791743 Francis, MB., Sorg, JA. (2016) Dipicolinic acid release by germinating Clostridium difficile spores occurs through a mechanosensing mechanism. mSphere 1(6):e00306-16. doi: 10.1128/mSphere.00306-16. Bhattacharjee, D., McAllister, KN., Sorg, JA. (2016) Germinants and their receptors in clostridia. J. Bacteriol. 2016 Jul 18. pii: JB.00405-16. |
Members of the Sorg Lab
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