Joe Sorg's lab in the Department of Biology at Texas A&M University investigates Clostridium difficile physiology and virulence with the end goal of developing novel antimicrobials to combat this pathogen.
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Clostridium difficile (C. diff) infections are a significant problem in the healthcare setting. Most commonly, patients who are treated with antibiotics for unrelated conditions are at risk of developing C. difficile infection. Symptoms include: diarrhea, fever, loss of appetite, nausea, belly pain / tenderness.
Infections caused by C. difficile can have a significant impact on a patient and a patient's family. Fortunately, there are support networks. If you, or someone you know, is suffering from C. difficile infections, please see the following sites for more information:
The Peggy Lillis Memorial Foundation
The Fecal Transplant Foundation
Recent PublicationsShrestha, R., Lockless, SW., Sorg, JA. (2017) A Clostridium difficile alanine racemase affects spore germination and accommodates serine as a substrate. J. Biol. Chem. Jun 23;292(25):10735-10742. doi: 10.1074/jbc.M117.791743
Francis, MB., Sorg, JA. (2016) Dipicolinic acid release by germinating Clostridium difficile spores occurs through a mechanosensing mechanism. mSphere 1(6):e00306-16. doi: 10.1128/mSphere.00306-16. Bhattacharjee, D., McAllister, KN., Sorg, JA. (2016) Germinants and their receptors in clostridia. J. Bacteriol. 2016 Jul 18. pii: JB.00405-16. Francis, MB., Sorg, JA. (2016) Detecting cortex fragments during bacterial spore germination. JoVE. 06/25/2016, Issue 112; doi: 10.3791/54146 Bhattacharjee, D., Francis, MB., Ding, X., McAllister, KN., Shrestha, R., Sorg, JA. (2016). Re-examining the germination phenotypes of several Clostridium difficile strains suggests another role for the CspC germinant receptor. J. Bacteriol. March; 198(5): 777-786 |
Members of the Sorg Lab
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